GSK-461364 ID:1623
Synonyms: |
CAS NO : 929095-18-1 |
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Molecular Formula: C27H28F3N5O2S |
Molecular Weight: 543.60373 |
Purity: 98% |
Solubility: In DMSO |
Storage: -20°C |
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Remarks:GSK-461364 is a Polo-like kinase 1 inhibitor, is also a small molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor GSK461364 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner.
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H-NMR,C-NMR,LC-MS,HPLC. |
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